Using graphene to protect DNA from cleavage during cellular delivery.
نویسندگان
چکیده
We have proved that functionalized nanoscale graphene oxide can protect oligonucleotides from enzymatic cleavage and efficiently deliver oligonucleotides into cells.
منابع مشابه
Using graphene to protect DNA from cleavage during cellular deliveryw
Genetic engineering holds great promise and opportunities for medicine and biomedical research. For example, RNA interference (RNAi) and antisense (AS) therapies are potentially powerful candidates for clinical treatments of various ailments, including cancer and AIDS. However, these therapeutic oligonucleotides are easily degraded by cellular enzymes or digested by cellular nucleases. Some mea...
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عنوان ژورنال:
- Chemical communications
دوره 46 18 شماره
صفحات -
تاریخ انتشار 2010